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Jag1tm1.1Loo
Targeted Allele Detail
Nomenclature
Symbol: Jag1tm1.1Loo
Name: jagged 1; targeted mutation 1.1, Kathleen M Loomes
MGI ID: MGI:3848155
Synonyms: Jag1loxP
Gene: Jag1  Location: Chr2:137081456-137116644 bp, - strand  Genetic Position: Chr2, 67.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:149131
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neomycin cassette was placed upstream of exon 4 with an additional loxP site placed downstream of exon 5. The neomycin cassette was removed by transient expression of cre recombinase leaving exons 4 and 5 floxed. Exon 4 encodes the DSL region, which is conserved across species and is known to be crucial for ligand-receptor interactions. Deletion of exon 4 and exon 5 by cre recombinase was predicted to result in a frameshift mutation and premature truncation of the protein after 192 amino acids. (J:149131)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jag1 Mutation:  8 strains or lines available
References
Original:  J:149131 Loomes KM, et al., Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage. Hepatology. 2007 Feb;45(2):323-30
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory