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Pidd1tm1.1Anvi
Targeted Allele Detail
Nomenclature
Symbol: Pidd1tm1.1Anvi
Name: p53 induced death domain protein 1; targeted mutation 1.1, Andreas Villunger
MGI ID: MGI:3847893
Synonyms: pidd-
Gene: Pidd1  Location: Chr7:141438113-141444025 bp, - strand  Genetic Position: Chr7, 86.79 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148929
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3-15 of the gene were replaced by the open reading frame of beta-galactosidase followed by a loxP flanked neo cassette. The loxP flanked neo cassette was removed in vivo by cre-mediated deletion. RT-PCR analysis confirmed the absence of mRNA in thymocytes and MEFs. Absence of protein product was confirmed by western blot of thymocyte extracts derived from homozygous mice. (J:148929)
Generation of the Pidd1tm1.1Anvi allele
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pidd1 Mutation:  30 strains or lines available
References
Original:  J:148929 Manzl C, et al., Caspase-2 activation in the absence of PIDDosome formation. J Cell Biol. 2009 Apr 20;185(2):291-303
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory