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Targeted Allele Detail
Symbol: Pidd1tm1.1Anvi
Name: p53 induced death domain protein 1; targeted mutation 1.1, Andreas Villunger
MGI ID: MGI:3847893
Synonyms: pidd-
Gene: Pidd1  Location: Chr7:141438113-141444025 bp, - strand  Genetic Position: Chr7, 86.79 cM
Germline Transmission:  Earliest citation of germline transmission: J:148929
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 3-15 of the gene were replaced by the open reading frame of beta-galactosidase followed by a loxP flanked neo cassette. The loxP flanked neo cassette was removed in vivo by cre-mediated deletion. RT-PCR analysis confirmed the absence of mRNA in thymocytes and MEFs. Absence of protein product was confirmed by western blot of thymocyte extracts derived from homozygous mice. (J:148929)
Generation of the Pidd1tm1.1Anvi allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pidd1 Mutation:  35 strains or lines available
Original:  J:148929 Manzl C, et al., Caspase-2 activation in the absence of PIDDosome formation. J Cell Biol. 2009 Apr 20;185(2):291-303
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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