Tg(SERPINA1)M2.03Slcw
Transgene Detail

Summary

• Symbol: Tg(SERPINA1)M2.03Slcw
• Name: transgene insertion M2.03, Savio L C Woo
• MGI ID: MGI:3847881
• Synonyms: M2.03, PiM
• Transgene: Tg(SERPINA1)M2.03Slcw Location: unknown
• Alliance: Tg(SERPINA1)M2.03Slcw page

Transgene origin

• Strain of Origin: (ICR x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgenic construct contained the entire wild-type human SERPINA1 gene (AAT, alpha₁-antitrypsin) with 2.0 and 2.3 kb of 5' and 3' genomic sequences, respectively. Multiple founder lines were generated and M2.03 with 50 copies of the transgene was chosen for the representative line. Efficient expression of SERPINA1 in mouse liver was obtained. (J:149133)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:149133 Sifers RN, et al., Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice. Nucleic Acids Res. 1987 Feb 25;15(4):1459-75
• All: 1 reference(s)