About   Help   FAQ
Pink1tm1Lex
Targeted Allele Detail
Summary
Symbol: Pink1tm1Lex
Name: PTEN induced putative kinase 1; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:3847806
Synonyms: Pink1tm1Ncw
Gene: Pink1  Location: Chr4:138040720-138053618 bp, - strand  Genetic Position: Chr4, 70.14 cM
Alliance: Pink1tm1Lex page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148903
Parent Cell Line:  Lex-2 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsAn IRES-lacZ/neo cassette replaced most of exon 2, and all of exons 3-5 as well as the intervening intronic sequences. Gene inactivation was confirmed by a lack of signal in immunoblot analysis of cortical neuron lysates. (J:148903)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pink1 Mutation:  42 strains or lines available
References
Original:  J:148903 Wood-Kaczmar A, et al., PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS One. 2008;3(6):e2455
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory