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Egln1tm1Pec
Targeted Allele Detail
Nomenclature
Symbol: Egln1tm1Pec
Name: egl-9 family hypoxia-inducible factor 1; targeted mutation 1, Peter Carmeliet
MGI ID: MGI:3847435
Synonyms: PHD2-
Gene: Egln1  Location: Chr8:124908596-124949254 bp, - strand  Genetic Position: Chr8, 72.86 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148719
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsLoxP flanked neo cassette replaced exon 2 of the gene. Absence of protein product was confirmed by western blot of homozygous embryos. (J:148719)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Egln1 Mutation:  3 strains or lines available
References
Original:  J:148719 Mazzone M, et al., Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell. 2009 Mar 6;136(5):839-51
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory