Tg(SMN2*)1951Ahmb
Transgene Detail

Summary

• Symbol: Tg(SMN2*)1951Ahmb
• Name: transgene insertion 1951, Arthur H M Burghes
• MGI ID: MGI:3847329
• Synonyms: line 1951, SMN(VDQNQKE)
• Transgene: Tg(SMN2*)1951Ahmb Location: unknown
• Alliance: Tg(SMN2*)1951Ahmb page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgenic construct encodes a truncated form of SMN2 (exons 1-6) with the added motif VDQNQKE under control of a 4.1 kb SMN2 promoter. Ten founder lines were obtained and lines 1946, 1947, and 1951 (which received more characterization) were established. (J:148541)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:148541 Workman E, et al., A SMN missense mutation complements SMN2 restoring snRNPs and rescuing SMA mice. Hum Mol Genet. 2009 Jun 15;18(12):2215-29
• All: 1 reference(s)