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Transgene Detail
Symbol: Tg(SMN2*A111G)591Ahmb
Name: transgene insertion 591, Arthur H M Burghes
MGI ID: MGI:3847326
Synonyms: A591, line 591, SMN(A111G), SMN(A11G)
Transgene: Tg(SMN2*A111G)591Ahmb  Location: unknown  
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(SMN2*A111G)591Ahmb expresses 1 gene
Mutation details: A transgenic construct containing the SMN(A111G) missense mutation under the control of 4.1 kb SMN promoter was injected into fertilized FVB/N mouse eggs. Ten founder lines were obtained and line 588 was subsequently established. This line was found to have 5 copies of the transgene. (J:148541)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:148541 Workman E, et al., A SMN missense mutation complements SMN2 restoring snRNPs and rescuing SMA mice. Hum Mol Genet. 2009 Jun 15;18(12):2215-29
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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