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Smurf2tm1Wran
Targeted Allele Detail
Nomenclature
Symbol: Smurf2tm1Wran
Name: SMAD specific E3 ubiquitin protein ligase 2; targeted mutation 1, Jeffrey Wrana
MGI ID: MGI:3846786
Gene: Smurf2  Location: Chr11:106820066-106920715 bp, - strand  Genetic Position: Chr11, 70.03 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148693
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 9 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on heart extracts. (J:148693)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smurf2 Mutation:  21 strains or lines available
References
Original:  J:148693 Narimatsu M, et al., Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell. 2009 Apr 17;137(2):295-307
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory