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Tg(FCER1A)1Bhk
Transgene Detail
Nomenclature
Symbol: Tg(FCER1A)1Bhk
Name: transgene insertion 1, Beverly H Koller
MGI ID: MGI:3846551
Synonyms: hFcepsilonR1alpha- hFcepsilonR1alpha+, hFcepsilonR1alphaTg
Transgene: Tg(FCER1A)1Bhk  Location: unknown  
Transgene
origin
Germline Transmission:  Earliest citation of germline transmission: J:113572
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(FCER1A)1Bhk expresses 1 gene
 
Mutation detailsThe transgenic construct contains the entire human Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, (FCER1A), including 2.9kb of upstream sequence. The transgene was coinjected with a plasmid containing the hprt minigene. These constructs were transfected into ES65-154 (E14TG2a-165) embryonic stem (ES). (J:113572)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
ES cells = ES65-154 (E14TG2a-165) cells
References
Original:  J:113572 Dombrowicz D, et al., Anaphylaxis mediated through a humanized high affinity IgE receptor. J Immunol. 1996 Aug 15;157(4):1645-51
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory