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Targeted Allele Detail
Symbol: Nelfbtm1.2Roli
Name: negative elongation factor complex member B; targeted mutation 1.2, Rong Li
MGI ID: MGI:3846131
Synonyms: Cobra1-
Gene: Nelfb  Location: Chr2:25199712-25211489 bp, - strand  Genetic Position: Chr2, 17.06 cM
No Nelfbtm1.2Roli/Nelfbtm1.2Roli embryos develop beyond E5

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:148508
Parent Cell Line:  iTL1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Germ line, cre mediated recombination removed exons 1 through 4. (J:148508)
Generation of the Nelfbtm1.1Roli and Nelfbtm1.2Roli alleles
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nelfb Mutation:  5 strains or lines available
Original:  J:148508 Amleh A, et al., Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis. PLoS One. 2009;4(4):e5034
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory