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Targeted Allele Detail
Symbol: Hmox1tm1.2Gkl
Name: heme oxygenase 1; targeted mutation 1.2, George Kollias
MGI ID: MGI:3846093
Synonyms: Hmox1D, HO-1KO
Gene: Hmox1  Location: Chr8:75093621-75100589 bp, + strand  Genetic Position: Chr8, 35.59 cM, cytoband C1
Chronic inflammatory disease in Hmox1tm1.2Gkl/Hmox1tm1.2Gkl mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:148498
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsGerm line, cre mediated recombination was used to remove exon 2 through 4. The absence of protein expression was confirmed by western blot analysis on thioglycollate-stimulated peritoneal macrophage. (J:148498)
Generation of Hmox1tm1.1Gkl and Hmox1tm1.2Gkl alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hmox1 Mutation:  21 strains or lines available
ES cell line = 129/3.
Original:  J:148498 Tzima S, et al., Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production. J Exp Med. 2009 May 11;206(5):1167-79
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory