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Hmox1tm1.2Gkl
Targeted Allele Detail
Nomenclature
Symbol: Hmox1tm1.2Gkl
Name: heme oxygenase 1; targeted mutation 1.2, George Kollias
MGI ID: MGI:3846093
Synonyms: Hmox1D, HO-1KO
Gene: Hmox1  Location: Chr8:75093591-75100596 bp, + strand  Genetic Position: Chr8, 35.59 cM, cytoband C1
Chronic inflammatory disease in Hmox1tm1.2Gkl/Hmox1tm1.2Gkl mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148498
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGerm line, cre mediated recombination was used to remove exon 2 through 4. The absence of protein expression was confirmed by western blot analysis on thioglycollate-stimulated peritoneal macrophage. (J:148498)
Generation of Hmox1tm1.1Gkl and Hmox1tm1.2Gkl alleles
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hmox1 Mutation:  19 strains or lines available
Notes
ES cell line = 129/3.
References
Original:  J:148498 Tzima S, et al., Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production. J Exp Med. 2009 May 11;206(5):1167-79
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory