Six2^{tm1(tTA,tetO-EGFP/cre)Amc}
Targeted Allele Detail

Summary

• Symbol: Six2^{tm1(tTA,tetO-EGFP/cre)Amc}
• Name: sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon
• MGI ID: MGI:3845218
• Synonyms: Six2Cre, Six2^{Tet-off-eGFPCre}, Six2^TGC, Six2-TGC
• Gene: Six2 Location: Chr17:85991705-85995702 bp, - strand Genetic Position: Chr17, 55.72 cM
• Alliance: Six2^{tm1(tTA,tetO-EGFP/cre)Amc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148455
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129/Sv x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase, Reporter, Transactivator)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Six2^{tm1(tTA,tetO-EGFP/cre)Amc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Six2 (MGI:102778)

• Mutation details: A targeting vector was designed to insert a Tet-off-eGFPCre and frt-flanked PGKneobpA selection cassette into the initiation codon of the Six2 (sine oculis-related homeobox 2 homolog (Drosophila)) targeted gene. (J:148455)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Six2 (mouse) Summary of all recombinase alleles driven by Six2. Alliance mouse Six2 gene page

Disease models

Expression

In Mice Carrying this Mutation:

4 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Six2^{tm1(tTA,tetO-EGFP/cre)Amc}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Six2 Mutation: 15 strains or lines available

References

• Original: J:148455 Kobayashi A, et al., Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell. 2008 Aug 7;3(2):169-81
• All: 23 reference(s)