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Ptgs2tm1Gaf
Targeted Allele Detail
Nomenclature
Symbol: Ptgs2tm1Gaf
Name: prostaglandin-endoperoxide synthase 2; targeted mutation 1, Garret A FitzGerald
MGI ID: MGI:3844713
Synonyms: CM-COX-2, COX-2flox
Gene: Ptgs2  Location: Chr1:150100031-150108227 bp, + strand  Genetic Position: Chr1, 63.84 cM, cytoband H1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148331
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 6, 7, and 8 that are critical for enzymatic function were flanked by loxP sites. PGE-2 production by activated peritoneal macrophages is unaffected in mice homozygous for this allele, indicating that gene function was not disrupted. (J:148331)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptgs2 Mutation:  14 strains or lines available
References
Original:  J:148331 Wang D, et al., Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7548-52
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory