Tg(Aqp2-icre)1Gsc
Transgene Detail

Summary

• Symbol: Tg(Aqp2-icre)1Gsc
• Name: transgene insertion 1, Gunther Schutz
• MGI ID: MGI:3843825
• Synonyms: AQP2Cre, Aqp2::iCre
• Transgene: Tg(Aqp2-icre)1Gsc Location: unknown
• Alliance: Tg(Aqp2-icre)1Gsc page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Aqp2-icre)1Gsc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Aqp2 (MGI:1096865)

• Mutation details: A PAC (RPCI21) containing a 125 kb 5'upstream region and 31.2 kb 3'downstream region of the mouse Aqp2 gene was modified by ET-recombination so that a cassette encoding a codon-improved cre recombinase sequence was inserted at the ATG of Aqp2. This modified fragment was injected into FVB/N oocyte pronuclei. A founder line with 2 copies of the transgene was established. (J:148058)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Aqp2 (mouse) Summary of all recombinase alleles driven by Aqp2. Comparative matrix view of recombinase activities Alliance mouse Aqp2 gene page

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:148058 Ronzaud C, et al., Impairment of sodium balance in mice deficient in renal principal cell mineralocorticoid receptor. J Am Soc Nephrol. 2007 Jun;18(6):1679-87
• All: 12 reference(s)