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Avptm1Lja
Targeted Allele Detail
Nomenclature
Symbol: Avptm1Lja
Name: arginine vasopressin; targeted mutation 1, J Larry Jameson
MGI ID: MGI:3843457
Synonyms: AvpC67X
Gene: Avp  Location: Chr2:130580620-130582554 bp, - strand  Genetic Position: Chr2, 63.24 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148012
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA floxed neo cassette was inserted in intron 1 and a C67X nonsense mutation was inserted in exon 2 via homologous recombination. The floxed neo cassette was then removed by Cre mediated recombination. RT-PCR confirmed the expression of mutant transcript in the hypothalamus. (J:148012)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Avp Mutation:  13 strains or lines available
References
Original:  J:148012 Russell TA, et al., A murine model of autosomal dominant neurohypophyseal diabetes insipidus reveals progressive loss of vasopressin-producing neurons. J Clin Invest. 2003 Dec;112(11):1697-706
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory