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Targeted Allele Detail
Symbol: Avptm1Hari
Name: arginine vasopressin; targeted mutation 1, Hiroshi Arima
MGI ID: MGI:3843456
Synonyms: FNDI
Gene: Avp  Location: Chr2:130580620-130582554 bp, - strand  Genetic Position: Chr2, 63.24 cM
Germline Transmission:  Earliest citation of germline transmission: J:147993
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA floxed pgk-neo cassette was inserted in intron 2 and a Cys98stop nonsense mutation was inserted in exon 2 via homologous recombination. The floxed neo cassette was then removed by Cre mediated recombination. Immunohistochemical analysis detected expression of a mutant protein in the supraoptic nucleus, the suprachiasmatic nuclei, and the paraventricular nucleus in homozygous and heterozygous mice. This analysis also confirmed the absence of wild-type protein expression in homozygous mice. (J:147993)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Avp Mutation:  10 strains or lines available
Original:  J:147993 Hayashi M, et al., Progressive polyuria without vasopressin neuron loss in a mouse model for familial neurohypophysial diabetes insipidus. Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1641-9
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory