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Sept12tm1.1Plk
Targeted Allele Detail
Nomenclature
Symbol: Sept12tm1.1Plk
Name: septin 12; targeted mutation 1.1, Pao-Lin Kuo
MGI ID: MGI:3843373
Gene: Sept12  Location: Chr16:4986858-4997852 bp, - strand  Genetic Position: Chr16, 2.49 cM, cytoband A1
Mutation
origin
Mouse Generated:  Earliest citation of chimera generation: J:147965
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted downstream of exon 2, and an additional loxP site was inserted downstream of exon 7. Transient cre expression in ES cells removed exons 3 through 7 along with the neo cassette. (J:147965)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sept12 Mutation:  14 strains or lines available
Notes
Chimeric male mice are sterile.
References
Original:  J:147965 Lin YH, et al., The expression level of septin12 is critical for spermiogenesis. Am J Pathol. 2009 May;174(5):1857-68
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory