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Ep300tm2Reck
Targeted Allele Detail
Nomenclature
Symbol: Ep300tm2Reck
Name: E1A binding protein p300; targeted mutation 2, Richard Eckner
MGI ID: MGI:3843052
Synonyms: p300AS-neo
Gene: Ep300  Location: Chr15:81586209-81652077 bp, + strand  Genetic Position: Chr15, 38.16 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85950
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsAcetyltransferase (AT) activity was ablated via the incorporation of engineered point mutations at the endogenous locus. The mutations substitute alanine and serine for tryptophan and tyrosine (WY(1466-1477)AS). This allele was used to generate Ep300tm1Reck. (J:85950)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ep300 Mutation:  62 strains or lines available
References
Original:  J:85950 Roth JF, et al., Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5. EMBO J. 2003 Oct 1;22(19):5186-96
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory