Ep300^tm2Reck
Targeted Allele Detail

Summary

• Symbol: Ep300^tm2Reck
• Name: E1A binding protein p300; targeted mutation 2, Richard Eckner
• MGI ID: MGI:3843052
• Synonyms: p300^AS-neo
• Gene: Ep300 Location: Chr15:81470329-81536278 bp, + strand Genetic Position: Chr15, 38.16 cM
• Alliance: Ep300^tm2Reck page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85950
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Acetyltransferase (AT) activity was ablated via the incorporation of engineered point mutations at the endogenous locus. The mutations substitute alanine and serine for tryptophan and tyrosine (WY(1466-1477)AS). This allele was used to generate Ep300^tm1Reck. (J:85950)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ep300 Mutation: 97 strains or lines available

References

• Original: J:85950 Roth JF, et al., Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5. EMBO J. 2003 Oct 1;22(19):5186-96
• All: 2 reference(s)