Cx3cr1^tm1.1Dpa
Targeted Allele Detail

Summary

• Symbol: Cx3cr1^tm1.1Dpa
• Name: C-X3-C motif chemokine receptor 1; targeted mutation 1.1, Dhavalkumar D Patel
• MGI ID: MGI:3842686
• Synonyms: Cx3cr1^{GFP KI}
• Gene: Cx3cr1 Location: Chr9:119877749-119897362 bp, - strand Genetic Position: Chr9, 71.37 cM
• Alliance: Cx3cr1^tm1.1Dpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147667
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette flanked by loxP sites and human CX3CR1-GFP fusion gene replaced the gene at the Cx3cr1 start codon inframe by homologous recombination. The neo cassette was subsequently removed by breeding to Cre transgenic mice. (J:147667)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cx3cr1 Mutation: 47 strains or lines available

References

• Original: J:147667 Liu P, et al., CX3CR1 deficiency impairs dendritic cell accumulation in arterial intima and reduces atherosclerotic burden. Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):243-50
• All: 2 reference(s)