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Cdkn2atm4Cjs
Targeted Allele Detail
Nomenclature
Symbol: Cdkn2atm4Cjs
Name: cyclin dependent kinase inhibitor 2A; targeted mutation 4, Charles J Sherr
MGI ID: MGI:3842647
Synonyms: ArfFL, ArfLoxP, Cdkn2aflx
Gene: Cdkn2a  Location: Chr4:89192710-89212856 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:147752
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe first coding exon (1Beta) is flanked by loxP sites. A loxP-neoTK-loxP cassette was inserted downstream of the floxed exon and was excised in the targeted ES cells. Cell clones with the selection cassette removed were used to generated mouse lines with a conditional Cdkn2a allele. (J:147752)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cdkn2a Mutation:  57 strains or lines available
References
Original:  J:147752 Gromley A, et al., Transient expression of the Arf tumor suppressor during male germ cell and eye development in Arf-Cre reporter mice. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6285-90
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory