Kmt5a^tm1.2Dare
Targeted Allele Detail

Summary

• Symbol: Kmt5a^tm1.2Dare
• Name: lysine methyltransferase 5A; targeted mutation 1.2, Danny Reinberg
• MGI ID: MGI:3842473
• Synonyms: PR-Set7^-
• Gene: Kmt5a Location: Chr5:124577993-124600371 bp, + strand Genetic Position: Chr5, 63.59 cM
• Alliance: Kmt5a^tm1.2Dare page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147765
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Germ line, cre mediated recombination was used to remove exon 7, which contains the SET domain. (J:147765)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt5a Mutation: 47 strains or lines available

References

• Original: J:147765 Oda H, et al., Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development. Mol Cell Biol. 2009 Apr;29(8):2278-95
• All: 2 reference(s)