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Targeted Allele Detail
Symbol: Achetm3Pata
Name: acetylcholinesterase; targeted mutation 3, Palmer Taylor
MGI ID: MGI:3842443
Synonyms: AChEdel E5/Neo
Gene: Ache  Location: Chr5:137288247-137294466 bp, + strand  Genetic Position: Chr5, 76.32 cM
Germline Transmission:  Earliest citation of germline transmission: J:147855
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Conditional ready, Hypomorph)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 5 was replaced with a floxed neo cassette. Ache serum activity is dramatically reduced compared to in wild-type mice, but can be restored by removal of the floxed cassette. (J:147855)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ache Mutation:  16 strains or lines available
Original:  J:147855 Camp S, et al., Acetylcholinesterase (AChE) gene modification in transgenic animals: functional consequences of selected exon and regulatory region deletion. Chem Biol Interact. 2005 Dec 15;157-158:79-86
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory