Tlr4^Lps-2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tlr4^Lps-2Btlr
• Name: toll-like receptor 4; defective lipopolysaccharide response 2 Bruce Beutler
• MGI ID: MGI:3842324
• Synonyms: Lps4, Tlr4^Lps4, defective lipopolysaccharide response 4
• Gene: Tlr4 Location: Chr4:66745788-66765338 bp, + strand Genetic Position: Chr4, 34.66 cM
• Alliance: Tlr4^Lps-2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was identified in a lipopolysaccharide (LPS)/nigericin responsiveness screen of G3 progeny of an ENU mutagenized male mouse. It comprises a G to A transition at nucleotide position 2192, in the third and last exon of the gene, which results in substitution of aspartic acid for glycine at amino acid position 724 (G724D); this amino acid, which resides within the alpha-beta helix of the protein-protein interacting TIR domain of the receptor, is conserved among TLR4 orthologs. (J:147339)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr4 Mutation: 90 strains or lines available

References

• Original: J:147339 Siggs O, et al., Record for "Lps4", updated April 15th, 2009. MGI Direct Data Submission. 2009
• All: 1 reference(s)