In(2Cd44;Hoxd11)2Ddu
Targeted Allele Detail

Summary

• Symbol: In(2Cd44;Hoxd11)2Ddu
• Name: inversion, Chr 2, Denis Duboule 2
• MGI ID: MGI:3840854
• Gene: In(2Cd44;Hoxd11)2Ddu Location: Chr2:74509902-102732010 bp Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100298
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S1/Sv and 129S2/SvPas and 129X1/SvJ

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Inversion
• In(2Cd44;Hoxd11)2Ddu involves 746 genes/genome features (A130042O14Rik, Olfr1190-ps1, Olfr1072-ps1 ...) View all
• Mutation details: A sequential targeted recombination-induced genomic (STRING) approach using parental strains Hoxd11^tm2.1Ddu and Cd44^tm1.1Ugu produced an inversion of an 11 cM region within a chromosome carrying Hoxd11 and Cd44. (J:100298)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any In(2Cd44;Hoxd11)2Ddu Mutation: 0 strains or lines available

References

• Original: J:100298 Spitz F, et al., Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes. Nat Genet. 2005 Aug;37(8):889-93
• All: 3 reference(s)