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Targeted Allele Detail
Symbol: Muc16tm1Bhr
Name: mucin 16; targeted mutation 1, Richard R Behringer
MGI ID: MGI:3840843
Gene: Muc16  Location: Chr9:18495518-18674530 bp, - strand  Genetic Position: Chr9, 7.06 cM, cytoband A3
Germline Transmission:  Earliest citation of germline transmission: J:147379
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 6 kb fragment including most of exon 3 and part of intron 3 was replaced with an IRES-T-lacZpA-loxP-PGKneobpA- loxP reporter cassette via homologous recombination. No lacZ expression was detected. RT-PCR confirmed the absence of transcripts containing exon 3 but detected alternatively spliced transcripts in the testis of homozygous mice. RT-PCR also confirmed the absence of all expression in the lung, ovary and oviduct from homozygous mice. Immunofluorescence did not detect protein expression in the testis from homozygous mice. (J:147379)
Generation of the Muc16tm1Bhr allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Muc16 Mutation:  8 strains or lines available
Original:  J:147379 Cheon DJ, et al., CA125/MUC16 is dispensable for mouse development and reproduction. PLoS One. 2009;4(3):e4675
All:  2 reference(s)

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MGI 6.11
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