Map4k2^tm1Jmky
Targeted Allele Detail

Summary

• Symbol: Map4k2^tm1Jmky
• Name: mitogen-activated protein kinase kinase kinase kinase 2; targeted mutation 1, John M Kyriakis
• MGI ID: MGI:3840555
• Synonyms: Gck^-
• Gene: Map4k2 Location: Chr19:6391165-6405645 bp, + strand Genetic Position: Chr19, 4.46 cM, cytoband A
• Alliance: Map4k2^tm1Jmky page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146772
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The genomic sequence spanning most of exon 1 through exon 22 was replaced with a STOP/neo cassette. The absence of protein expression in bone marrow macrophages and peripheral blood leukocytes. (J:146772)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map4k2 Mutation: 44 strains or lines available

References

• Original: J:146772 Zhong J, et al., GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38. (RETRACTED Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5134). Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4372-7
• All: 1 reference(s)