Map4k2tm1Jmky
Targeted Allele Detail
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Symbol: |
Map4k2tm1Jmky |
Name: |
mitogen-activated protein kinase kinase kinase kinase 2; targeted mutation 1, John M Kyriakis |
MGI ID: |
MGI:3840555 |
Synonyms: |
Gck- |
Gene: |
Map4k2 Location: Chr19:6391165-6405645 bp, + strand Genetic Position: Chr19, 4.46 cM, cytoband A
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Alliance: |
Map4k2tm1Jmky page
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Germline Transmission: |
Earliest citation of germline transmission:
J:146772
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The genomic sequence spanning most of exon 1 through exon 22 was replaced with a STOP/neo cassette. The absence of protein expression in bone marrow macrophages and peripheral blood leukocytes.
(J:146772)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Map4k2 Mutation: |
44 strains or lines available
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Original: |
J:146772 Zhong J, et al., GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38. (RETRACTED Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5134). Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4372-7 |
All: |
1 reference(s) |
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