Mecp2^tm2.1Jae
Targeted Allele Detail

Summary

• Symbol: Mecp2^tm2.1Jae
• Name: methyl CpG binding protein 2; targeted mutation 2.1, Rudolf Jaenisch
• MGI ID: MGI:3840527
• Synonyms: Mecp2^S80A
• Gene: Mecp2 Location: ChrX:73070198-73129296 bp, - strand Genetic Position: ChrX, 37.63 cM
• Alliance: Mecp2^tm2.1Jae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147157
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Germ line, cre mediated recombination was used to remove the floxed neo/STOP cassette allowing for expression of the protein with the amino acid substitution of alanine for serine at position 80. (J:147157)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mecp2 Mutation: 38 strains or lines available

References

• Original: J:147157 Tao J, et al., Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4882-7
• All: 3 reference(s)