Ptpn11^tm7Bgn
Targeted Allele Detail

Summary

• Symbol: Ptpn11^tm7Bgn
• Name: protein tyrosine phosphatase, non-receptor type 11; targeted mutation 7, Benjamin Neel
• MGI ID: MGI:3840251
• Synonyms: ND, Ptpn11^N308D, Ptpn11^tm2.1Toa
• Gene: Ptpn11 Location: Chr5:121268596-121329460 bp, - strand Genetic Position: Chr5, 61.72 cM, cytoband F
• Alliance: Ptpn11^tm7Bgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147154
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A targeting construct consisting of a floxed neo cassette and sequence encoding for an N308D mutation were inserted via homologous recombination. The neo cassette was then removed via Cre mediated recombination. (J:147154)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptpn11 Mutation: 43 strains or lines available

References

• Original: J:147154 Araki T, et al., Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4736-41
• All: 2 reference(s)