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Ptpn11tm1Toa
Targeted Allele Detail
Nomenclature
Symbol: Ptpn11tm1Toa
Name: protein tyrosine phosphatase, non-receptor type 11; targeted mutation 1, Toshiyuki Araki
MGI ID: MGI:3840248
Synonyms: inDY, Ptpn11inD61Y
Gene: Ptpn11  Location: Chr5:121130533-121191397 bp, - strand  Genetic Position: Chr5, 61.72 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:147154
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ptpn11 Mutation:  20 strains or lines available
References
Original:  J:147154 Araki T, et al., Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4736-41
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory