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Targeted Allele Detail
Symbol: Ptpn11tm6Bgn
Name: protein tyrosine phosphatase, non-receptor type 11; targeted mutation 6, Benjamin Neel
MGI ID: MGI:3840248
Synonyms: inDY, Ptpn11inD61Y, Ptpn11tm1Toa
Gene: Ptpn11  Location: Chr5:121268596-121329460 bp, - strand  Genetic Position: Chr5, 61.72 cM, cytoband F
Germline Transmission:  Earliest citation of germline transmission: J:147154
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA cassette consisting of a loxP site, neo, loxP site, stop signal, and a third loxP site was inserted into intron 2 and a D61Y mutation was inserted into exon 3 via homologous recombination. (J:147154, J:148430)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ptpn11 Mutation:  35 strains or lines available
Original:  J:147154 Araki T, et al., Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4736-41
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory