Tg(MPO*-463G)1Wfr
Transgene Detail

Summary

• Symbol: Tg(MPO*-463G)1Wfr
• Name: transgene insertion 1, Wanda F Reynolds
• MGI ID: MGI:3839892
• Synonyms: MPOG
• Transgene: Tg(MPO*-463G)1Wfr Location: unknown
• Alliance: Tg(MPO*-463G)1Wfr page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MPO*-463G)1Wfr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MPO (4353)

  Mpo	(MGI:97137)

• Mutation details: A construct containing a 32-kb BST11071 restriction fragment including the human gene with 7 kb of upstream and 11 kb of downstream sequence, and containing the human functional upstream promoter polymorphism, -463GA (G allele) was used to create transgenic mice. This polymorphism is contained within a conserved sequence recognized by various nuclear receptors. Only one founder mouse was obtained. (J:130052)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:130052 Kumar AP, et al., Peroxisome proliferator-activated receptor gamma ligands regulate myeloperoxidase expression in macrophages by an estrogen-dependent mechanism involving the -463GA promoter polymorphism. J Biol Chem. 2004 Feb 27;279(9):8300-15
• All: 6 reference(s)