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Grb10tm1Fuis
Targeted Allele Detail
Summary
Symbol: Grb10tm1Fuis
Name: growth factor receptor bound protein 10; targeted mutation 1, Fumitoshi Ishino
MGI ID: MGI:3839150
Synonyms: Meg1deltaDMRneo
Gene: Grb10  Location: Chr11:11880499-11987428 bp, - strand  Genetic Position: Chr11, 7.15 cM
Alliance: Grb10tm1Fuis page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:146865
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1b was replaced with a floxed neo cassette. At E12.5, mice exhibit 1.65-fold greater than wild-type biallelic expression of the type I transcript that lacks the differentially methylated region (DMR). (J:146865)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grb10 Mutation:  53 strains or lines available
References
Original:  J:146865 Shiura H, et al., Paternal deletion of Meg1/Grb10 DMR causes maternalization of the Meg1/Grb10 cluster in mouse proximal Chromosome 11 leading to severe pre- and postnatal growth retardation. Hum Mol Genet. 2009 Apr 15;18(8):1424-38
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory