Tg(Msx2-lacZ)1Rem
Transgene Detail

Summary

• Symbol: Tg(Msx2-lacZ)1Rem
• Name: transgene insertion 1, Robert Maxson
• MGI ID: MGI:3838972
• Transgene: Tg(Msx2-lacZ)1Rem Location: unknown
• Alliance: Tg(Msx2-lacZ)1Rem page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: In mice with this transgene, the E. coli beta-galactosidase (lacZ) coding sequence is expressed from a minimal promoter under control of a tetrameric repeat of the bone morphogenic protein (BMP) responsive enhancer (BMPRE), a 52 base pair sequence that is located between nucleotides -3523 and -3471 upstream of the mouse homeobox, msh-like 2 (Msx2) gene and comprises the "core element" required for BMP responsiveness. Beta-galactosidase activity in transgenic embryos partially recapitulates the spatiotemporal expression pattern of endogenous Msx2. (J:93586)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Mice homozygous for the transgene exhibit slightly stronger beta-galactosidase expression than do hemizygous transgenic mice. Both male and female hemizygotes and homozygous females are fertile; the fertility status of homozygous male mice is not known.

References

• Original: J:93586 Brugger SM, et al., A phylogenetically conserved cis-regulatory module in the Msx2 promoter is sufficient for BMP-dependent transcription in murine and Drosophila embryos. Development. 2004 Oct;131(20):5153-65
• All: 3 reference(s)