Oxtrtm2.1Knis
Targeted Allele Detail
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Symbol: |
Oxtrtm2.1Knis |
Name: |
oxytocin receptor; targeted mutation 2.1, Katsuhiko Nishimori |
MGI ID: |
MGI:3838764 |
Synonyms: |
OxtrVenusdeltaNeo |
Gene: |
Oxtr Location: Chr6:112450644-112466904 bp, - strand Genetic Position: Chr6, 52.27 cM, cytoband E3
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Alliance: |
Oxtrtm2.1Knis page
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Germline Transmission: |
Earliest citation of germline transmission:
J:146587
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Parent Cell Line: |
E14TG2a (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Part of exon 3 was replaced with a modified version of a yellow fluorescent protein gene (Venus) and a floxed pgk-neo cassette was inserted in intron 3 via homologous recombination. The neo cassette was then removed by Cre mediated recombination. RT-PCR and autoradiogram analysis confirmed the absence of RNA expression and binding activity in brains from homozygous mice.
(J:146587)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Oxtr Mutation: |
40 strains or lines available
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Original: |
J:146587 Yoshida M, et al., Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. J Neurosci. 2009 Feb 18;29(7):2259-71 |
All: |
20 reference(s) |
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