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Cacna1ftm1.1Sdie
Targeted Allele Detail
Nomenclature
Symbol: Cacna1ftm1.1Sdie
Name: calcium channel, voltage-dependent, alpha 1F subunit; targeted mutation 1.1, Susanne tom Dieck
MGI ID: MGI:3838717
Synonyms: Cacna1fdeltaEx14-17
Gene: Cacna1f  Location: ChrX:7607103-7635196 bp, + strand  Genetic Position: ChrX, 3.42 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:146683
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGerm line, cre mediated recombination was used to remove exons 14 through 17. Expression of a truncated protein was confirmed by western blot analysis on retinal extracts. (J:146683)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cacna1f Mutation:  17 strains or lines available
References
Original:  J:146683 Specht D, et al., Effects of presynaptic mutations on a postsynaptic Cacna1s calcium channel colocalized with mGluR6 at mouse photoreceptor ribbon synapses. Invest Ophthalmol Vis Sci. 2009 Feb;50(2):505-15
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory