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Transgene Detail
Symbol: Tg(Scnn1a-cre)2Aibs
Name: transgene insertion 2, Ed Lein
MGI ID: MGI:3838498
Synonyms: Scnna1-Tg2-Cre
Transgene: Tg(Scnn1a-cre)2Aibs  Location: unknown  
Strain of Origin:  (C57BL/6 x C3H)F1 x C57BL/6
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
Mutation detailsThe 196 kb C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-405B24, containing the entire Scnn1a locus (and other genes), was modified by targeting a Cre recombinase coding sequence (the CreERT2 sequence modified back to encode the normal Cre recombinase gene), SV40 polyA signal, and frt-flanked neomycin cassette to the ATG start site of the Scnn1a locus. The targeted BAC sequences were further modified using FLP recombination to remove the selection cassette and linearized to remove its original vector backbone. Cre expression is directed to cortex, thalamus, midbrain and cerebellum by the Scnn1a promoter/enhancer regions within the BAC transgene. (J:146821, J:155793)
 Tissue activity of this recombinase allele
Driver: Scnn1a     Summary of all recombinase alleles driven by Scnn1a. Comparative matrix view of recombinase activities

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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:155793 Madisen L, et al., A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci. 2010 Jan;13(1):133-40
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory