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Tg(Wfs1-cre/ERT2)3Aibs
Transgene Detail
Nomenclature
Symbol: Tg(Wfs1-cre/ERT2)3Aibs
Name: transgene insertion 3, Ed Lein
MGI ID: MGI:3838496
Synonyms: Wfs1-Tg3-CreERT2
Transgene: Tg(Wfs1-cre/ERT2)3Aibs  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x C3H)F1 x C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsThe 196 kb C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-405O19, containing the entire Wsf1 locus (and other genes), was modified by targeting a CreERT2 fusion gene (Cre-ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain), SV40 polyA signal, and frt-flanked neomycin cassette to the ATG start site of the Wsf1 locus. The targeted BAC sequences were further modified using FLP recombination to remove the selection cassette and linearized to remove its original vector backbone. Cre activity is directed to cortex, hippocampus, striatum, thalamus and cerebellum only following taxomifen administration. (J:146821, J:155793)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Wfs1     Summary of all recombinase alleles driven by Wfs1. Comparative matrix view of recombinase activities
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:155793 Madisen L, et al., A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci. 2010 Jan;13(1):133-40
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory