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Targeted Allele Detail
Symbol: Usp1tm1.1Ada
Name: ubiquitin specific peptidase 1; targeted mutation 1.1, Alan D D'Andrea
MGI ID: MGI:3838373
Synonyms: Usp1-
Gene: Usp1  Location: Chr4:98812047-98823780 bp, + strand  Genetic Position: Chr4, 45.6 cM
Germline Transmission:  Earliest citation of germline transmission: J:146616
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExon 3 was flanked by loxP sites with a FRT-flanked neomycin resistance cassette placed downstream. Before microinjection into blastocystes, the neomycin cassette was excised by transient expression of Flp-recombinase. Mice were crossed with EIIa-cre transgenic mice to remove the floxed allele. No protein was detected by immunoblot analysis of homozygote embryonic fibroblast lysates. (J:146616)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Usp1 Mutation:  28 strains or lines available
Original:  J:146616 Kim JM, et al., Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype. Dev Cell. 2009 Feb;16(2):314-20
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
The Jackson Laboratory