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Targeted Allele Detail
Symbol: Ttrtm1Kymm
Name: transthyretin; targeted mutation 1, Ken-ichi Yamamura
MGI ID: MGI:3838181
Synonyms: Ttr-
Gene: Ttr  Location: Chr18:20665280-20674321 bp, + strand  Genetic Position: Chr18, 11.47 cM
Germline Transmission:  Earliest citation of germline transmission: J:146510
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout, RMCE-ready)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA null allele was created by replacing the ATG start site within exon 1 with a PGK-neo cassette flanked by lox71 and loxP sites. Besides disrupting the gene, the cassette also serve as an acceptor in recombination mediated cassette exchange. No protein was detected in immunoblot analysis of homozygote livers. (J:146510)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ttr Mutation:  24 strains or lines available
Original:  J:146510 Zhao G, et al., Inconsistency between hepatic expression and serum concentration of transthyretin in mice humanized at the transthyretin locus. Genes Cells. 2008 Nov 13;13(12):1257-1268
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory