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Transgene Detail
Symbol: Tg(Myh6-MYL2*D166V)1Dsc
Name: transgene insertion 1, Danuta Szczesna-Cordary
MGI ID: MGI:3838172
Synonyms: Tg-D166V
Transgene: Tg(Myh6-MYL2*D166V)1Dsc  Location: unknown  
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Myh6-MYL2*D166V)1Dsc expresses 1 gene
Mutation detailsThe mouse cardiac alpha myosin heavy chain promoter along with the first two exons and part of the third was used to drive cardiac-specific expression of a mutated human cDNA derived from patient with familial hypertrophic cardiomyopathy that contains an amino acid substitution of valine for aspartic acid at position 166 (D166V). No line information was given. (J:146091)
View phenotypes for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:146091 Kerrick WG, et al., Malignant familial hypertrophic cardiomyopathy D166V mutation in the ventricular myosin regulatory light chain causes profound effects in skinned and intact papillary muscle fibers from transgenic mice. FASEB J. 2009 Mar;23(3):855-65
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory