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Targeted Allele Detail
Symbol: Col1a1tm2(CAG-EGFR*)Char
Name: collagen, type I, alpha 1; targeted mutation 2, Al Charest
MGI ID: MGI:3837826
Synonyms: Col1alpha1-EGFRvIII
Gene: Col1a1  Location: Chr11:94936224-94953042 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:146494
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, No functional change)
Mutation:    Insertion
Col1a1tm2(CAG-EGFR*)Char expresses 1 gene
Mutation detailsA CAG promoter was used to drive expression the oncogenic variant vIII of human EGFR with an intervening floxed STOP cassette inserted into the 3' untranslated region. The mutant form contains an in-frame deletion of exons 2 through 7 and codes for a ligand independent receptor. (J:146494)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:  72 strains or lines available
Original:  J:146494 Zhu H, et al., Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2712-6
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
The Jackson Laboratory