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Targeted Allele Detail
Symbol: Rev3ltm1.1Rsky
Name: REV3 like, DNA directed polymerase zeta catalytic subunit; targeted mutation 1.1, Klaus Rajewsky
MGI ID: MGI:3837725
Synonyms: Pol-zetadelta
Gene: Rev3l  Location: Chr10:39732118-39875211 bp, + strand  Genetic Position: Chr10, 21.04 cM
Chromosome aberrations in B cells of Rev3ltm1Rsky/Rev3ltm1.1Rsky Tg(Cr2-cre)3Cgn/0 mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:146453
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsMice carrying the Rev3ltm1Rsky allele were crossed with cre deleter mice to remove the floxed exon. Exon excision was confirmed by gene amplification and subsequent sequencing of the PCR product. This is considered a null allele. (J:146453)
Generation of the Rev3ltm1Rsky and Rev3ltm1.1Rsky alleles
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rev3l Mutation:  47 strains or lines available
Original:  J:146453 Schenten D, et al., Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability. J Exp Med. 2009 Feb 16;206(2):477-90
All:  1 reference(s)

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last database update
MGI 6.06
The Jackson Laboratory