Tg(Lck-Smarce1*K112I)1Grc
Transgene Detail

Summary

• Symbol: Tg(Lck-Smarce1*K112I)1Grc
• Name: transgene insertion 1, Gerald R Crabtree
• MGI ID: MGI:3837675
• Synonyms: K112I
• Transgene: Tg(Lck-Smarce1*K112I)1Grc Location: unknown
• Alliance: Tg(Lck-Smarce1*K112I)1Grc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Lck-Smarce1*K112I)1Grc expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Smarce1 (MGI:1927347)	Transgene codes for a protein with a lysine to isoleucine mutation.

• Mutation details: The Lck proximal promoter was used to direct expression in transgenic mice of a BAF57 (Smarce1) cDNA bearing a point mutation (K112I) that disrupts DNA binding. (J:131676)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:131676 Chi TH, et al., Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature. 2002 Jul 11;418(6894):195-9
• All: 2 reference(s)