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Tg(CSNK1D*,-EGFP)816Yfu
Transgene Detail
Nomenclature
Symbol: Tg(CSNK1D*,-EGFP)816Yfu
Name: transgene insertion 816, Ying-Hui Fu
MGI ID: MGI:3837569
Synonyms: hCKIdelta-T44A L, Tg(CSNK1D*)816Yfu
Transgene: Tg(CSNK1D*,-EGFP)816Yfu  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Tg(CSNK1D*,-EGFP)816Yfu expresses 1 gene
 
Mutation detailsThe human BAC clone RP11-1376P16 containing the CSNK1D gene was targeted to generate a threonine-to-alanine mutation at amino acid 44 in the protein (T44A). An IRES-GFP cassette was also inserted after the stop codon of the CSNK1D gene. Six lines were generated with 4 of the lines 498, 503, 816 and 830, being low expressers due to insertion of only one copy of the transgene. Transgene expression was confirmed by RT-PCR of brain lysates. This is a representative record for the four low expressing lines. (J:97658)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:97658 Xu Y, et al., Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome. Nature. 2005 Mar 31;434(7033):640-4
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory