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Tg(CSNK1D*,-EGFP)827Yfu
Transgene Detail
Nomenclature
Symbol: Tg(CSNK1D*,-EGFP)827Yfu
Name: transgene insertion 827, Ying-Hui Fu
MGI ID: MGI:3837566
Synonyms: hCKIdelta-T44A H, Tg(CSNK1D*)827Yfu
Transgene: Tg(CSNK1D*,-EGFP)827Yfu  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Tg(CSNK1D*,-EGFP)827Yfu expresses 1 gene
 
Mutation detailsThe human BAC clone RP11-1376P16 containing the CSNK1D gene was targeted to generate a threonine-to-alanine alteration at amino acid 44 in the protein (T44A). An IRES-GFP cassette was also inserted after the stop codon of the CSNK1D gene. Six lines were generated with two of the lines, 827 and 859, being high expressers due to insertion of 2 to 3 copies of the transgene. Transgene expression was confirmed by RT-PCR of brain lysates. This is a representative record for the two high expressing lines. (J:97658)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:97658 Xu Y, et al., Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome. Nature. 2005 Mar 31;434(7033):640-4
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory