Gpr68^tm1Aha
Targeted Allele Detail

Summary

• Symbol: Gpr68^tm1Aha
• Name: G protein-coupled receptor 68; targeted mutation 1, Akihiro Harada
• MGI ID: MGI:3837434
• Synonyms: OGR1^geo
• Gene: Gpr68 Location: Chr12:100842941-100874457 bp, - strand Genetic Position: Chr12, 51.1 cM
• Alliance: Gpr68^tm1Aha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146233
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing a bcl2 splice acceptor (SA) and a FRT-flanked beta-geo gene was inserted into the PvuII site upstream of exon 2. A loxP site was included upstream of the cassette and another loxP site was inserted into the BglII site in intron 3. Gene transcription is interrupted by the strong splice acceptor and terminated by a polyA sequence in the beta-geo gene. (J:146233, J:189192)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr68 Mutation: 23 strains or lines available

References

• Original: J:146233 Mogi C, et al., Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages. J Immunol. 2009 Mar 1;182(5):3243-51
• All: 2 reference(s)