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Tg(ACTB-Peo1*)DSuom
Transgene Detail
Nomenclature
Symbol: Tg(ACTB-Peo1*)DSuom
Name: transgene insertion D, Anu Suomalainen
MGI ID: MGI:3836897
Synonyms: Twinkledup
Transgene: Tg(ACTB-Peo1*)DSuom  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(ACTB-Peo1*)DSuom expresses 1 gene
 
Mutation detailsThe human promoter was used to drive ubiquitous expression of the mouse gene with a silent point mutation at position 1077 (c.1077C->G) that forms a restriction enzyme site and allows for the insertion of 39 nucleotides. This produces a duplication of amino acids 353 to 365. Four lines were produced (C, D, E, and F) with line D selected as the representative line. (J:104378)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:104378 Tyynismaa H, et al., Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice. Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17687-92
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory