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Sh2d1b1tm2Vei
Targeted Allele Detail
Nomenclature
Symbol: Sh2d1b1tm2Vei
Name: SH2 domain containing 1B1; targeted mutation 2, Andre Veillette
MGI ID: MGI:3836736
Synonyms: EAT-2-
Gene: Sh2d1b1  Location: Chr1:170277320-170286769 bp, + strand  Genetic Position: Chr1, 76.84 cM, cytoband H2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:145969
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsES cells carrying the Sh2d1b2tm1Vei (ERT) null allele were targeted again with a hygromycin cassette to the Sh2d1b1 locus to create a second null allele. The two null alleles were in cis with each other, and were located 26 kb apart. (J:145969)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sh2d1b1 Mutation:  2 strains or lines available
References
Original:  J:145969 Cruz-Munoz ME, et al., Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat Immunol. 2009 Mar;10(3):297-305
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory