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Targeted Allele Detail
Symbol: Mark3tm1Hpw
Name: MAP/microtubule affinity regulating kinase 3; targeted mutation 1, Helen Piwnica-Worms
MGI ID: MGI:3836595
Synonyms: cTak KO, Par-1a-
Gene: Mark3  Location: Chr12:111574523-111656221 bp, + strand  Genetic Position: Chr12, 61.05 cM, cytoband F2
Germline Transmission:  Earliest citation of germline transmission: J:163905
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA 1.9 kb fragment of the gene was disrupted by the insertion of a neomycin resistance cassette. Exon 2 (hosting the ATP binding site) and the 5' slice site of intron 2/3 were shifted out of frame. Multi-tissue Western blotting confirmed ablation of this gene in all tissues of homozygous null-mice.
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mark3 Mutation:  51 strains or lines available
Original:  J:163905 Lennerz JK, et al., Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis and defective gluconeogenesis. Mol Cell Biol. 2010 Aug 23;
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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