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Targeted Allele Detail
Symbol: Cdc25atm1.1Hpw
Name: cell division cycle 25A; targeted mutation 1, Helen Piwnica-Worms
MGI ID: MGI:3836586
Synonyms: A-, Cdc25A-
Gene: Cdc25a  Location: Chr9:109704647-109722963 bp, + strand  Genetic Position: Chr9, 59.81 cM
Cdc25atm1.1Hpw/Cdc25atm1.1Hpw embryos undergo apoptosis during postimplantation development

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:145768
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was introduce 5' of exon 1 and a loxP-flanked selection cassette was introduced to intron 3 via 129X1/SvJ-derived RW4 embryonic stem (ES) cells. ES cell clones containing the recombinant allele were expanded and transiently transfected with a plasmid encoding Cre recombinase under the control of the CMV promoter to remove exons 1-3 and the selection cassette. (J:145768)
Generation of the Cdc25atm1Hpw and Cdc25atm1.1Hpw alleles
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdc25a Mutation:  26 strains or lines available
Original:  J:145768 Lee G, et al., Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4701-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory